Tetraphenyl piperazine-1,4-diyldiphosphonate
نویسندگان
چکیده
The mol-ecule of the title compound, C(28)H(28)N(2)O(6)P(2), is organized around an inversion center located at the centre of the piperazine ring. Both piperazine N atoms are substituted by P(O)(OC(6)H(5))(2) phospho-ester groups. The P atoms display a slightly distorted tetra-hedral environment; the N atoms show some deviation from planarity. The O atoms of the P=O groups are involved in inter-molecular C-H⋯O hydrogen bonds, building R(2) (2)(22) rings, in extended chains parallel to the a axis. C-H⋯π inter-actions involving the phenyl rings further stabilize the packing.
منابع مشابه
Comparative Computational Studies of 1,4-Diformyl-piperazine and 1,4-Dithionyl-Piperazine
The molecular properties known to play an essential role in drug-receptor interaction of substructures models of bioactive molecules have been studied using chemical quantum calculations. 1,4-diformyl-piperazine and 1,4-dithionyl-piperazine have been used as models to probe conformational behaviors and some electronic properties of substructure of some tri-substituted piperazine showing dual an...
متن کاملVirtual Screening and Biological Evaluation of Piperazine Derivatives as Human Acetylcholinesterase Inhibitors
The piperazine derivatives have been shown to inhibit human acetylcholinesterase. Virtual screening by molecular docking of piperazine derivatives 1-(1,4-benzodioxane-2-carbonyl) piperazine (K), 4-(4-methyl)-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S1), and 4-(4-chloro)-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S3) has been shown to bind at peripheral anioni...
متن کامل1,4-Bis(4-nitrosophenyl)piperazine: novel bridging ligand in dinuclear complexes of rhodium(III) and iridium(III).
The synthesis, spectroscopic characterization and crystal structures of the first 1,4-bis(4-nitrosophenyl)piperazine (BNPP) (4) bridged dinuclear complexes of rhodium(III) and iridium(III) are presented. The reaction of the μ(2)-halogenido-bridged dimers [(η(5)-C(5)Me(5))IrX(2)](2) [X = Cl (5a), Br (5b), I (5c)] and [(η(5)- C(5)Me(5))RhCl(2)](2) (6a) with 4 yields the dinuclear complexes [(η(5)...
متن کاملThree-dimensional network in piperazine-1,4-diium–picrate–piperazine (1/2/1)
In the title compound, C(4)H(12)N(2) (2+)·2C(6)H(2)N(3)O(7) (-)·C(4)H(10)N(2), the piperazine-1,4-diium cations and piperazine mol-ecules lie on crystallographic inversion centres. In the crystal structure, inter-molecular N-H⋯O and N-H⋯N hydrogen bonds link the components to form two-dimensional layers parallel to the (001) plane. These layers are, in turn, connected by weak inter-molecular C-...
متن کاملPreliminary evaluation of anticonvulsant activity and neurotoxicity of some 1,4-substituted piperazine derivatives.
A series of 1,4-piperazine derivatives was synthesized and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX). The compounds were only moderately effective. The anticonvulsant activity was accompanied by neurotoxicity. 1-[(4-Chlor-3-methylphenoxy)-acetyl]-4-(2-methoxyphe...
متن کامل